产品说明书
α-Estradiol
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同义名 : | α-雌二醇 ;Epiestrol;Epiestradiol;Pantostin;Ell-Cranell Alpha;Avixis;Avicis;17α-Oestradiol;NSC 20293;17-epi Estradiol;17α-Estradiol;17 α-E2;Alora;17alpha-Estradiol;Alfatradiol;Alpha-Estradiol |
| CAS号 : | 57-91-0 | |
| 货号 : | A533159 | |
| 分子式 : | C18H24O2 | |
| 纯度 : | 95% | |
| 分子量 : | 272.382 | |
| MDL号 : | MFCD00064144 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 60 mg/mL(220.28 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 无水乙醇: 10 mg/mL(36.71 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | α-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Inhibition of the Testosterone Metabolism in Rat Liver Slices by 17 alpha-Estradiol[3]. α-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression[4]. α-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. α-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. α-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups[5]. Seventeen α-estradiol (17α-E2) increase insulin sensitivity and extend lifespan in male mice, with less robust effects in female mice. 17α-E2 treatment decreased the number of primordial follicles in GHRKO (Growth hormone receptor knockout) mice. GHRKO mice displayed lesser primordial follicle activation as compared to wild type mice, but this phenotype was reversed by 17α-E2 administration, suggesting that ovarian aging is increased by 17α-E2 in long-living mice with extended reproductive longevity[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.67mL 0.73mL 0.37mL |
18.36mL 3.67mL 1.84mL |
36.71mL 7.34mL 3.67mL |
| 参考文献 |
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