Rbin-1

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Chemical Structure| 328023-11-6 同义名 : Ribozinoindole-1
CAS号 : 328023-11-6
货号 : A530038
分子式 : C13H12N4S
纯度 : 99%+
分子量 : 256.326
MDL号 : MFCD02369534
存储条件：

Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(117.04 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Rbin-1 is a potent, reversible and specific eukaryotic ribosome biogenesis inhibitor targeting on Mdn1. Rbin-1 at 1μM inhibited Mdn1’s ATPase activity in vitro. Rbin-1 allowed inhibition of Mdn1-dependent pre-60S ribosome biogenesis in fission yeast cells on fast timescales. Treatment with Rbin-1 at 1μM reduced the level of Rix1-bound Ytm1 and Rsa4 Rix1 particles in fission yeast cells. Inhibition of Mdn1 by Rbin-1 reduced the recruition of ribosome assembly factors, such as Rix7, by Mdn1.
作用机制 Rbin-1 could directly target Mdn1, possibly by inhibiting its ATPase activity.[1]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.90mL

0.78mL

0.39mL

19.51mL

3.90mL

1.95mL

39.01mL

7.80mL

3.90mL
参考文献

[1]Kawashima SA, Chen Z, et al. Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Cell. 2016 Oct 6;167(2):512-524.e14.