产品说明书

UPF-648

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Chemical Structure| 213400-34-1 同义名 : (±)-DBCC
CAS号 : 213400-34-1
货号 : A529761
分子式 : C11H8Cl2O3
纯度 : 99+%
分子量 : 259.085
MDL号 : MFCD25976753
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

无水乙醇: 50 mg/mL(192.99 mM)，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 UPF-648 is a potent kynurenine 3-monooxygenase (KMO) inhibitor, exhibits highly active at 1 μM(81 ± 10% KMO inhibition), and is ineffective at blocking KAT activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.86mL

0.77mL

0.39mL

19.30mL

3.86mL

1.93mL

38.60mL

7.72mL

3.86mL
参考文献

[1]Amori L, Guidetti P, et al. On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J Neurochem. 2009 Apr;109(2):316-25.

[2]Ceresoli-Borroni G, Guidetti P, et al. Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. J Neurosci Res. 2007 Mar;85(4):845-54.