产品说明书
Fenobam
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同义名 : | - |
| CAS号 : | 57653-26-6 | |
| 货号 : | A529486 | |
| 分子式 : | C11H11ClN4O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 266.684 | |
| MDL号 : | MFCD00868019 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(393.72 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Fenobam is a selective, orally active antagonist of mGluR5 with an IC50 of 84 nM and the ability to cross the blood-brain barrier. The Kd values of Fenobam for rat and human recombinant mGlu5 receptors are 54 nM and 31 nM, respectively. Fenobam exhibits anti-anxiety properties, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells. It is used in research related to neurological disorders, cancer, and drug addiction[1][2][3]. At a concentration of 300 μM, a 72-hour treatment with Fenobam significantly inhibits the proliferation of LM7 cells and induces apoptosis[2]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01981395 | Hyperalgesia ... 展开 >>Allodynia 收起 << | Phase 1 | Completed | - | United States, Missouri ... 展开 >> Washington University School of Medicine St. Louis, Missouri, United States, 63110 收起 << |
| NCT01806415 | Healthy | Phase 1 | Completed | - | United States, Missouri ... 展开 >> Washington University School Of Medicine St. Louis, Missouri, United States, 63110 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.75mL 0.75mL 0.37mL |
18.75mL 3.75mL 1.87mL |
37.50mL 7.50mL 3.75mL |
| 参考文献 |
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