产品说明书

Decursinol angelate

Print
Chemical Structure| 130848-06-5 同义名 : 紫花前胡醇当归酸酯
CAS号 : 130848-06-5
货号 : A529270
分子式 : C19H20O5
纯度 : 99%+
分子量 : 328.359
MDL号 : MFCD06796687
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(319.77 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. Decursinol angelate also inhibits PGE2-induced expression of cyclooxygenase-2 and the activation of the Ras/Raf/Erk pathway, which activates downstream targets for cell survival. Decursinol angelate greatly reduces the PGE2-induced activation of NF-κB p50 and p65 subunits. It has been reported to suppress the growth of estrogen-stimulated and estrogen-independent growth and survival of breast cancer MCF-7 and MDA-MB-231 cells. Decursinol angelate also suppresses the growth of cancer cells through the inhibition of phosphatidylinositol 3'-kinase (PI3K)/Akt, extracellular-signal-regulated kinase (Erk) and nuclear factor-κB (NFκB). Decursinol angelate has anti-leukemic activity through the suppression of protein kinase C activation in human leukemia cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.30mL

15.23mL

3.05mL

1.52mL

30.45mL

6.09mL

3.05mL