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VU0364289

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Chemical Structure| 1242443-29-3 同义名 : -
CAS号 : 1242443-29-3
货号 : A525448
分子式 : C20H21N3O2
纯度 : 97%
分子量 : 335.4
MDL号 : MFCD26097260
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 VU0364289 is a novel N-aryl piperaxine mGlu5 positive allosteric modulator (EC50=1.6μM). VU0364289 induced robust leftward shifts in the glutamate concentration-response curves for Ca(2+) mobilization and extracellular signal-regulated kinases 1 and 2 phosphorylation. VU0364289 possessed suitable pharmacokinetic properties for dosing in vivo and produced robust dose-related effects in reversing amphetamine-induced hyperlocomotion, a preclinical model predictive of antipsychotic-like activity.[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.98mL

0.60mL

0.30mL

14.91mL

2.98mL

1.49mL

29.82mL

5.96mL

2.98mL
参考文献

[1]Gregory KJ, Herman EJ, Ramsey AJ, et al. N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement. J Pharmacol Exp Ther. 2013;347(2):438-457.