产品说明书

Sobetirome

Print
Chemical Structure| 211110-63-3 同义名 : GC-1;QRX-431
CAS号 : 211110-63-3
货号 : A523942
分子式 : C20H24O4
纯度 : 98%
分子量 : 328.402
MDL号 : MFCD19443713
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(319.73 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Sobetirome is a member of a class of compounds known as selective thyromimetics.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.30mL

15.23mL

3.05mL

1.52mL

30.45mL

6.09mL

3.05mL
参考文献

[1]Gierach I, Li J, et al. Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1. FEBS Open Bio. 2012 Aug 15;2:247-53.

[2]Johansson L, Rudling M, et al. Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10297-302.