产品说明书

Velutin

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Chemical Structure| 25739-41-7 同义名 : -
CAS号 : 25739-41-7
货号 : A523500
分子式 : C17H14O6
纯度 : 98%+
分子量 : 314.289
MDL号 : MFCD20260863
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(159.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Velutin, a natural product isolated and purified from the leaves of Vernonia flexuosa with anti-inflammatory property, exhibits the greatest potency among all flavones in reducing TNF-α and IL-6 production and shows the strongest inhibitory effect in nuclear factor (NF)-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK phosphorylation.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.18mL

0.64mL

0.32mL

15.91mL

3.18mL

1.59mL

31.82mL

6.36mL

3.18mL
参考文献

[1]Xie C, Kang J, et al. The acai flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway. J Nutr Biochem. 2012 Sep;23(9):1184-91.

[2]Ng TB, Lam JS, et al. Differential abilities of the mushroom ribosome-inactivating proteins hypsin and velutin to perturb normal development of cultured mouse embryos. Toxicol In Vitro. 2010 Jun;24(4):1250-7.