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Dextran sulfate sodium, mw 40,000

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Chemical Structure| 9011-18-1 同义名 : 葡聚糖硫酸钠 ;DSS, mw 40,000
CAS号 : 9011-18-1
货号 : A523162
分子式 : (C6H7Na3O14S3)n
纯度 : M.W 40000
分子量 : 0
MDL号 : MFCD00081551
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • HIV Protease
描述 Dextran sulfate sodium salt (MW ~40,000) is a is a polymer of anhydroglucose with the molecular weight range of ~40,000. Dextran sulfate sodium salt inhibits the replication of the human immunodeficiency virus by preventing the adsorption of the virus into host cells. The molecular weight of DSS to be an important factor in the murine model of colitis. In the 5 kD group, colitis was observed predominantly in the cecum and upper colon. Colitis in the 40 kD group was more severe than that in the 5 kD group, and in the 40 kD group it was more severe in the lower colon than in the upper colon.
参考文献

[1]Baba M, et al. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6132-6.

[2]Kitajima S, Takuma S, Morimoto M. Histological analysis of murine colitis induced by dextran sulfate sodium of different molecular weights. Exp Anim. 2000 Jan;49(1):9-15. doi: 10.1538/expanim.49.9. PMID: 10803356.

[3]Ma F, Song Y, Sun M, Wang A, Jiang S, Mu G, Tuo Y. Exopolysaccharide Produced by Lactiplantibacillus plantarum-12 Alleviates Intestinal Inflammation and Colon Cancer Symptoms by Modulating the Gut Microbiome and Metabolites of C57BL/6 Mice Treated by Azoxymethane/Dextran Sulfate Sodium Salt. Foods. 2021 Dec 9;10(12):3060.