生物活性 | |||
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靶点 |
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描述 | ML216 (CID-49852229) acts as a powerful, selective, and cell-penetrable blocker of BLM helicase's DNA unwinding function, exhibiting IC50 values of 2.98 μM for BLM full-length and 0.97 μM for BLM636-1298. Additionally, ML216 suppresses BLM's ssDNA-dependent ATPase activity with a Ki of 1.76 µM, displaying antitumor activity[1][2]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.61mL 0.52mL 0.26mL |
13.04mL 2.61mL 1.30mL |
26.09mL 5.22mL 2.61mL |
参考文献 |
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