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Daptomycin

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Chemical Structure| 103060-53-3 同义名 : LY146032
CAS号 : 103060-53-3
货号 : A520357
分子式 : C72H101N17O26
纯度 : 98%
分子量 : 1620.67
MDL号 : MFCD08282794
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(64.79 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(61.7 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • DNA synthesis
描述 Daptomycin exhibits strong in vitro inhibitory and bactericidal activity against a range of bacterial strains. It is notably effective against nafcillin-susceptible and resistant staphylococci with a MIC90 (minimum inhibitory concentration for 90% of organisms) of ≤0.5 mg/L, and against enterococci with a MIC90 of ≤2.0 mg/L. Daptomycin demonstrates greater efficacy than vancomycin against most isolates tested. It stands out as the most potent agent against nafcillin-resistant staphylococci and ranks among the most effective treatments for enterococci, excluding trimethoprim-sulfamethoxazole. Notably, both daptomycin and vancomycin exhibit an increase in MIC when the bacterial inoculum is increased from 105 to 107 nM cfu/mL, suggesting a dose-dependent response to larger bacterial populations[1]. Daptomycin's efficacy is contained within a relatively narrow concentration range, from 0.125 to 2.0 mg/mL, showing higher activity compared to other agents tested against S. faecalis [2]. Additionally, daptomycin has been found to inhibit the formation of nucleotide-linked intermediates in bacterial biosynthetic processes[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.62mL

0.12mL

0.06mL

3.09mL

0.62mL

0.31mL

6.17mL

1.23mL

0.62mL
参考文献

[1]Benson CA, et al. Comparative in-vitro activity of LY146032 a new peptolide, with vancomycin and eight other agents against gram-positive organisms. J Antimicrob Chemother. 1987 Aug;20(2):191-6.

[2]Miniter PM, et al. Activity of LY146032 in vitro and in experimental enterococcal pyelonephritis. Antimicrob Agents Chemother. 1987 Aug;31(8):1199-203.

[3]Allen NE, et al. Inhibition of peptidoglycan biosynthesis in gram-positive bacteria by LY146032. Antimicrob Agents Chemother. 1987 Jul;31(7):1093-9.