Bisantrene

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Chemical Structure| 78186-34-2 同义名 : CL216942;CS1
CAS号 : 78186-34-2
货号 : A518842
分子式 : C22H22N8
纯度 : 95+%
分子量 : 398.464
MDL号 : MFCD00872137
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(2.51 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Bisantrene, recognized for its potent antitumor properties, achieves its cytotoxic effects through DNA intercalation. It specifically interacts with eukaryotic type II topoisomerases and is also identified as a substrate for MDR1[1][2][3][4]. Bisantrene enhances DNase I cleavage at oligopurine-oligopyrimidine sequences and marginally diminishes the cleavage at alternating purine-pyrimidine sequences[1]. Bisantrene acts as an inhibitor of [3H]uridine integration into RNA and [3H]thymidine integration into DNA[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.51mL

0.50mL

0.25mL

12.55mL

2.51mL

1.25mL

25.10mL

5.02mL

2.51mL
参考文献

[1]Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54(6):1036-45.

[2]Yap HY, et al. Bisantrene, an active new drug in the treatment of metastatic breast cancer. Cancer Res. 1983 Mar;43(3):1402-4.

[3]Wang BS, et al. Activation of tumor-cytostatic macrophages with the antitumor agent 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazole-2-yl)hydrazone] dihydrochloride (bisantrene). Cancer Res. 1984 Jun;44(6):2363-7.

[4]Aksentijevich I, et al. Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity. Clin Cancer Res. 1996 Jun;2(6):973-80.