产品说明书

MK-4965

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Chemical Structure| 920035-77-4 同义名 : -
CAS号 : 920035-77-4
货号 : A517525
分子式 : C20H13Cl2N5O2
纯度 : 98+%
分子量 : 426.255
MDL号 : MFCD18782715
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 MK-4965 is a nonnucleoside reverse transcriptase inhibitor with anti-viral activity. MK-4965 possesses the desired properties for further development as an NNRTI for the treatment of HIV-1 infection.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.35mL

0.47mL

0.23mL

11.73mL

2.35mL

1.17mL

23.46mL

4.69mL

2.35mL
参考文献

[1]Lai MT, Munshi V, et al. Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2009 Jun;53(6):2424-31.

[2]Tucker TJ, Sisko JT, et al. Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b] pyridine-3-yl)methoxy] -2-chlorophenoxy}-5-chloro benzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses. J Med Chem. 2008 Oct 23;51(20):6503-11.