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Veliparib 2HCl

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Chemical Structure| 912445-05-7 同义名 : ABT-888 dihydrochloride;ABT-888 (hydrochloride);Veliparib;Veliparib dihydrochloride
CAS号 : 912445-05-7
货号 : A516702
分子式 : C13H18Cl2N4O
纯度 : 99%
分子量 : 317.214
MDL号 : MFCD12407402
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 3 mg/mL(9.46 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 250 mg/mL(788.11 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Veliparib dihydrochloride is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.15mL

0.63mL

0.32mL

15.76mL

3.15mL

1.58mL

31.52mL

6.30mL

3.15mL
参考文献

[1]Penning TD, Zhu GD, et al. Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl] -1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. J Med Chem. 2009 Jan 22;52(2):514-23.

[2]Donawho CK, Luo Y, et al. ABT-888, an orally active poly(ADP-ribose)polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res. 2007 May 1;13(9):2728-37.