产品说明书
Cucurbitacin E
 |
同义名 : | α-Elaterin;α-Elaterine;NSC 521775;NSC 106399 |
| CAS号 : | 18444-66-1 | |
| 货号 : | A513376 | |
| 分子式 : | C32H44O8 | |
| 纯度 : | 99%+ | |
| 分子量 : | 556.687 | |
| MDL号 : | MFCD00135936 | |
| 存储条件： |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 50 mg/mL(89.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Cyclin-dependent kinases (CDKs) are a group of multifunctional enzymes consisting of catalytic and regulatory subunits[3]. Cucurbitacin E is a natural compound which from the climbing stem of Cucumic melo L. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex. in vitro study is initiated in which each of the CRC cell lines is exposed to increasing doses of Cucurbitacin E (0, 2.5, 5, and 7.5 μM) over a period of 24 h. Cucurbitacin E is shown to induce morphological changes in the primary colon cancer cells. A remarkable change in morphology was observed in the period of 6 and 24 h. Cucurbitacin E inhibits tumor growth by arresting the cell cycle in the G2/M phase via GADD45γ gene expression and the blockage of cyclin B1/CDC2 complex in primary CRC cells[4]. A high fat diet mice model of metabolic syndrome (HFD-MetS) is developed to assess the role of Cucurbitacin E (CuE) on body weight and fat tissue biology. Results showed a significant decrease in body weights of mice treated with Cucurbitacin E (0.5mg/kg) and central obesity is also reduced after the treatment[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02858388 | Otitis Media With Effusion | Phase 3 | Completed | - | Italy ... 展开 >> San Gennaro Hospital Naples, Italy, 80136 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.80mL 0.36mL 0.18mL |
8.98mL 1.80mL 0.90mL |
17.96mL 3.59mL 1.80mL |
| 参考文献 |
|---|