Rimiducid

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Chemical Structure| 195514-63-7 同义名 : Ap1903
CAS号 : 195514-63-7
货号 : A512669
分子式 : C78H98N4O20
纯度 : 99%+
分子量 : 1411.628
MDL号 : MFCD25976784
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(74.38 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Rimiducid (AP1903) induces a strong and dose-dependent apoptotic death in these genetically modified cells in vitro, with an effective concentration 50 (EC50) of approximately 0.1 nM[1]. The peak elimination occurs at Rimiducid concentrations of 3 to 10 nM, and the IC50 is around 0.2 nM.LV′VFas-transduced T lymphocytes, which display elevated CD25 levels, are eradicated with a 66%±7.5% (n=10) efficiency. Post-treatment with Rimiducid, once CD25 levels revert to baseline, 63%±4.7% (n=9) cell death is noted[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.71mL

0.14mL

0.07mL

3.54mL

0.71mL

0.35mL

7.08mL

1.42mL

0.71mL
参考文献

[1]Clackson T, et al. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10437-42.

[2]Thomis DC, et al. A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease. Blood. 2001 Mar 1;97(5):1249-57.