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Lysipressin

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Chemical Structure| 50-57-7 同义名 : Lysine vasopressin;[Lys8]-Vasopressin
CAS号 : 50-57-7
货号 : A512243
分子式 : C46H65N13O12S2
纯度 : 98%
分子量 : 1056.218
MDL号 : MFCD00076754
存储条件:

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

H2O: 100 mg/mL(94.68 mM)

动物实验配方:
生物活性
描述 Arginine vasopressin, a nine-amino acid peptide that is secreted from the posterior pituitary in response to high plasma osmolality and hypotension, is central in the hypothalamic-neurohypophyseal-vasopressin pathway. Vasopressin has important roles in circulatory and water homoeostasis mediated by vasopressin receptor subtypes V1a (vascular), V1b (pituitary), and V2 (vascular, renal)[3]. It is assumed that arginine vasopressin found in most mammals is the product of two identical genes which can be revealed in some species by differential mutations as seen usually in marsupials[4]. Additional duplications followed by point mutation of the vasopressin gene seem to have occurred in several marsupial families. It is of interest to find this putative duplication in both Australian and American marsupials[5]. Lysipressin is a kind of antidiuretic hormone that has been found in pigs and some marsupial families[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.95mL

0.19mL

0.09mL

4.73mL

0.95mL

0.47mL

9.47mL

1.89mL

0.95mL

参考文献

[1]Gorbulev V, Buchner H, et al. Molecular cloning and functional characterization of V2 [8-lysine] vasopressin and oxytocin receptors from a pig kidney cell line. Eur J Biochem. 1993 Jul 1;215(1):1-7.

[2]Crankshaw D. [Arg8] vasopressin-induced contractions of rabbit urinary bladder smooth muscle. Eur J Pharmacol. 1989 Dec 7;173(2-3):183-8.

[3]Tamma G, Goswami N, Reichmuth J, De Santo NG, Valenti G. Aquaporins, vasopressin, and aging: current perspectives. Endocrinology. 2015 Mar;156(3):777-88. doi: 10.1210/en.2014-1812. Epub 2014 Dec 16. PMID: 25514088.

[4]Chauvet MT, Colne T, Hurpet D, Chauvet J, Acher R. A multigene family for the vasopressin-like hormones? Identification of mesotocin, lysipressin and phenypressin in Australian macropods. Biochem Biophys Res Commun. 1983 Oct 14;116(1):258-63. doi: 10.1016/0006-291x(83)90409-6. PMID: 6639661.

[5]Acher R. The nonmammalian-mammalian transition through neurohypophysial peptides. Peptides. 1985;6 Suppl 3:309-14. doi: 10.1016/0196-9781(85)90390-0. PMID: 3831965.

[6]Rouille Y, Chauvet MT, Chauvet J, Acher R, Hadley ME. The distribution of lysine vasopressin (lysipressin) in placental mammals: a reinvestigation of the Hippopotamidae (Hippopotamus amphibius) and Tayassuidae (Tayassu angulatus) families. Gen Comp Endocrinol. 1988 Sep;71(3):475-83. doi: 10.1016/0016-6480(88)90277-8. PMID: 3192070.