N-Descyclopropanecarbaldehyde Olaparib

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Chemical Structure| 763111-47-3 同义名 : -
CAS号 : 763111-47-3
货号 : A510198
分子式 : C20H19FN4O2
纯度 : 97%
分子量 : 366.39
MDL号 : MFCD18251631
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(286.58 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib that includes a DOTA moiety. This compound serves as a CRBN-based ligand for the synthesis of novel dual EGFR and PARP PROTACs, specifically DP-C-4[1]. Additionally, N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled with F-18 or a fluorophore for applications in positron emission tomography (PET) or optical imaging, making it valuable for tumor diagnostics and research[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.73mL

0.55mL

0.27mL

13.65mL

2.73mL

1.36mL

27.29mL

5.46mL

2.73mL
参考文献

[1]Tao Huang, et al. Initial evaluation of Cu-64 labeled PARPi-DOTA PET imaging in mice with mesothelioma. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3472-3476.

[2]Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.