ML314

产品说明书

Print
Chemical Structure| 1448895-09-7 同义名 : -
CAS号 : 1448895-09-7
货号 : A508285
分子式 : C24H28N4O3
纯度 : 98%
分子量 : 420.504
MDL号 : MFCD28009370
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(118.9 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9 μM) and shows good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.89mL

2.38mL

1.19mL

23.78mL

4.76mL

2.38mL
参考文献

[1]Barak LS, Bai Y, et al. ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse. ACS Chem Biol. 2016 Jul 15;11(7):1880-90.

[2]Peddibhotla S, Hedrick MP, et al. Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor. ACS Med Chem Lett. 2013 Jul 20;4(9):846-851.