产品说明书

Atractylenolide I

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Chemical Structure| 73069-13-3 同义名 : 苍术内酯I
CAS号 : 73069-13-3
货号 : A506949
分子式 : C15H18O2
纯度 : 99%
分子量 : 230.302
MDL号 : MFCD09037395
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(455.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Atractylenolide I, a natural compound extracted from largehead atractylodes rhizome, induces apoptosis and brings about cytotoxicity of human promyeloleukemic HL-60 cells. It is also a TLR4-antagonizing agent.
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
HepG2 cells Function assay Transactivation of p53 in human HepG2 cells expressing MDM2 promoter by transient transfection reporter assay 22365756
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.34mL

0.87mL

0.43mL

21.71mL

4.34mL

2.17mL

43.42mL

8.68mL

4.34mL
参考文献

[1]Zhang JL, Huang WM, et al. Atractylenolide I protects mice from lipopolysaccharide-induced acute lung injury. Eur J Pharmacol. 2015 Oct 15;765:94-9.

[2]Li CQ, He LC, et al. Atractylenolide I and atractylenolide III inhibit Lipopolysaccharide-induced TNF-alpha and NO production in macrophages. Phytother Res. 2007 Apr;21(4):347-53.