BML-210

产品说明书

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Chemical Structure| 537034-17-6 同义名 : N-phenyl-N'-(2-Aminophenyl)hexamethylenediamide;CAY10433
CAS号 : 537034-17-6
货号 : A503709
分子式 : C20H25N3O2
纯度 : 98%
分子量 : 339.431
MDL号 : MFCD08062139
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(88.38 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BML-210 acts as a strong inhibitor of HDAC, able to suppress the HDAC4-VP16-driven reporter activity with an IC50 of approximately 5 µM. It specifically disrupts the HDAC4:MEF2 interaction, leads to an accumulation of cells in the G0/G1 phase, and promotes apoptosis, demonstrating antitumor efficacy in orthotopic mammary tumors in mice[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.29mL

14.73mL

2.95mL

1.47mL

29.46mL

5.89mL

2.95mL
参考文献

[1]Nimanthi Jayathilaka, et al. Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Res. 2012 Jul; 40(12): 5378–5388.

[2]Veronika Borutinskaite, et al. The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming. Int J Mol Sci. 2015 Aug; 16(8): 18252–18269.

[3]Zhuolong Zhou, et al. An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity. Nat Biomed Eng. 2021 Nov;5(11):1320-1335.