产品说明书

DHODH-IN-17

Print
Chemical Structure| 16344-26-6 同义名 : -
CAS号 : 16344-26-6
货号 : A501481
分子式 : C12H9ClN2O2
纯度 : 97%
分子量 : 248.665
MDL号 : MFCD03114306
存储条件:

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 85 mg/mL(341.83 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 DHODH-IN-17, a 2-anilino nicotinic acid derivative, acts as an inhibitor of human DHODH with an IC50 of 0.40 µM. It is suitable for research on acute myeloid leukemia (AML)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.02mL

0.80mL

0.40mL

20.11mL

4.02mL

2.01mL

40.21mL

8.04mL

4.02mL

参考文献

[1]Lewis TA, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016;7(12):1112-1117.