Canrenoate potassium

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Chemical Structure| 2181-04-6 同义名 : 刊利酸钾 ;Aldadiene potassium;SC-14266
CAS号 : 2181-04-6
货号 : A501269
分子式 : C22H29KO4
纯度 : 98%
分子量 : 396.562
MDL号 : MFCD05662375
存储条件:

Pure form 2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

H2O: 100 mg/mL(252.17 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方:
生物活性
描述 Potassium canrenoate, the potassium salt of canrenoic acid, is an aldosterone antagonist of the spirolactone group.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01059136 Myocardial Infarction Phase 3 Completed - France ... 展开 >> Hôpital PITIE-SALPETRIERE - Institut de Cardiologie Paris, France, 75013 收起 <<
NCT01882179 ST-elevation Myocardial Infarc... 展开 >>tion 收起 << Phase 3 Completed - United Kingdom ... 展开 >> Cardiothoracic Center - Basildon and Thurrock University Hospitals Basildon, Essex, United Kingdom, SS16 5NL Leeds Genereal Infirmary Leeds, United Kingdom London Chest Hospital London, United Kingdom, E2 9JX Heart Hospital London London, United Kingdom, W1G 8PH 收起 <<
NCT00741663 Cirrhosis Asc... 展开 >>ites 收起 << Phase 4 Completed - Italy ... 展开 >> University of Padova, Dept. of Clinical and Experimental Medicine Padova, Italy, 35100 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.61mL

2.52mL

1.26mL

25.22mL

5.04mL

2.52mL

参考文献

[1]Alexandre J, Beygui F, et al. Electrophysiological and antiarrhythmic properties of potassium canrenoate during myocardial ischemia-reperfusion. J Cardiovasc Pharmacol Ther. 2015 May;20(3):313-21.

[2]Bos R, Mougenot N, et al. Potassium canrenoate, an aldosterone receptor antagonist, reduces isoprenaline-induced cardiac fibrosis in the rat. J Pharmacol Exp Ther. 2004 Jun;309(3):1160-6.