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Arginase inhibitor 1

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Chemical Structure| 1345808-25-4 同义名 : -
CAS号 : 1345808-25-4
货号 : A500151
分子式 : C13H27BN2O4
纯度 : 98+%
分子量 : 286.175
MDL号 : MFCD28167713
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(174.72 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(104.83 mM)
动物实验配方：
生物活性
描述 Arginase inhibitor 1 is a potent small molecule inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.49mL

0.70mL

0.35mL

17.47mL

3.49mL

1.75mL

34.94mL

6.99mL

3.49mL
参考文献

[1]Van Zandt MC, Whitehouse DL, et al. Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem. 2013 Mar 28;56(6):2568-80.