N-acetylcysteine amide

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Chemical Structure| 38520-57-9 同义名 : NACA;N-acetyl-L-Cysteine amide;Nac amide
CAS号 : 38520-57-9
货号 : A497963
分子式 : C5H10N2O2S
纯度 : 98%
分子量 : 162.21
MDL号 : MFCD01696115
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(647.31 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 200 mg/mL(1232.97 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 N-Acetylcysteine amide had no significant effect on the viability of doxorubicin-treated H9c2 cells at less than 1 mM, but produced significant cytotoxicity at 10-20 mM. N-Acetylcysteine amide at a concentration of 750 μM reduced doxorubicin-induced ROS concentration and lipid peroxidation, and restored the GSH/GSSG ratio and the activities of antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR)[1].N-Acetylcysteine amide at a concentration of 1 mM protected human brain microvascular endothelial cells (HBMVEC) from methamphetamine-induced cell death[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.16mL

1.23mL

0.62mL

30.82mL

6.16mL

3.08mL

61.65mL

12.33mL

6.16mL
参考文献

[1]Shi R, et al. N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes. BMC Pharmacol. 2009 Apr 15;9:7.

[2]Zhang X, et al. N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells. Brain Res. 2009 Jun 12;1275:87-95.

[3]Pandya JD, et al. N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Exp Neurol. 2014 Jul;257:106-13.