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1-Ethynylpyrene

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Chemical Structure| 34993-56-1 同义名 : 1-乙炔基嵌二萘
CAS号 : 34993-56-1
货号 : A496061
分子式 : C18H10
纯度 : 98%
分子量 : 226.272
MDL号 : -
存储条件:

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 8 mg/mL(35.36 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 1-Ethynylpyrene is an aryl acetylenic inhibitor of cytochromes P450 1A1, 1A2, and 2B1, demonstrating IC50s of 0.18, 0.32, and 0.04 μM, respectively[1]. 1-Ethynylpyrene functions as a click chemistry reagent, featuring an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.42mL

0.88mL

0.44mL

22.10mL

4.42mL

2.21mL

44.19mL

8.84mL

4.42mL

参考文献

[1]Naijue Zhu, et al. Ethynyl and Propynylpyrene Inhibitors of Cytochrome P450. J Chem Crystallogr. 2010 Apr 1;40(4):343-352.