ASP5878

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Chemical Structure| 1453208-66-6 同义名 : -
CAS号 : 1453208-66-6
货号 : A494813
分子式 : C18H19F2N5O4
纯度 : 99%
分子量 : 407.371
MDL号 : MFCD30532771
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(613.69 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • FGFR2

    FGFR2, IC50:0.6 nM

  • FGFR3

    FGFR3, IC50:0.74 nM

  • FGFR4

    FGFR4, IC50:3.5 nM

  • FGFR1

    FGFR1, IC50:0.47 nM
描述 ASP5878 is a selective FGFR inhibitor, to treat FGFR3-dependent urothelial cancer with or without chemoresistance.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.45mL

0.49mL

0.25mL

12.27mL

2.45mL

1.23mL

24.55mL

4.91mL

2.45mL
参考文献

[1]Kikuchi A, Suzuki T, et al. ASP5878, a selective FGFR inhibitor, to treat FGFR3-dependent urothelial cancer with or without chemoresistance. Cancer Sci. 2017 Feb;108(2):236-242.

[2]Futami T, Okada H, et al. ASP5878, a Novel Inhibitor of FGFR1, 2, 3, and 4, Inhibits the Growth of FGF19-Expressing Hepatocellular Carcinoma. Mol Cancer Ther. 2017 Jan;16(1):68-75.