产品说明书

N-Acetyl-D-mannosamine Monohydrate

Print
Chemical Structure| 3615-17-6 同义名 : N-乙酰基-β-D-甘露糖胺 ;N-Acetylmannosamine;ManNAc;N-Acetyl-D-mannosamine
CAS号 : 3615-17-6
货号 : A494199
分子式 : C8H15NO6
纯度 : 98%
分子量 : 221.208
MDL号 : MFCD00046758
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 120 mg/mL(542.48 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 N-Acetyl-D-mannosamine (ManNAc) serves as a crucial precursor to N-acetylneuraminic acid (NeuAc), which is the specific monomer found in bacterial capsular polysialic acid (PA)[1]. N-Acetyl-D-mannosamine (ManNAc) undergoes metabolism by GNE and GlcNAc 2-epimerase (Renin binding protein, RnBP) into ManNAc-6-phosphate and GlcNAc, respectively. Additionally, N-Acetyl-D-mannosamine (ManNAc) and its derivatives stimulate hypocretin (HCRT) gene expression in orexin neurons, offering a potential framework for evaluating treatments for neural disorders[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.52mL

0.90mL

0.45mL

22.60mL

4.52mL

2.26mL

45.21mL

9.04mL

4.52mL
参考文献

[1]Revilla-Nuin B, et al. Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. FEBS Lett. 2002 Jan 30;511(1-3):97-101.

[2]Hayakawa K, et al. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 2017 Sep;12(9):764-778.