Indole

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Chemical Structure| 120-72-9 同义名 : -
CAS号 : 120-72-9
货号 : A493773
分子式 : C8H7N
纯度 : 98%
分子量 : 117.15
MDL号 : MFCD00005607
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(896.3 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 3 mg/mL(25.61 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 Indole is an endogenous metabolite. Indole, as an interspecies and interkingdom signaling molecule, plays important roles in bacterial pathogenesis and eukaryotic immunity. Furthermore, indole and its derivatives are viewed as potential antivirulence compounds against antibiotic-resistant pathogens because of their ability to inhibit quorum sensing and virulence factor production. Indole modulates oxidative stress, intestinal inflammation, and hormone secretion in animals, and it controls plant defense systems and growth. Insects and nematodes can recognize indole, which controls some of their behavior[1]. Indole administered IV (femoral vein) produced a dose-dependent increase in BP (Arterial blood pressure) but not HR (heart rate). In contrast, the ICV (lateral ventricle of the brain) infusion of indole produced a decrease in BP and HR. Indole and indoxyl sulfate affect arterial blood pressure via peripheral and central mechanisms dependent on serotonin signalling[2]. Discovery of new indole-based tubulin polymerization inhibitors will continue to dominate the synthetic efforts of many medicinal chemists working in the field[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

8.54mL

1.71mL

0.85mL

42.68mL

8.54mL

4.27mL

85.36mL

17.07mL

8.54mL
参考文献

[1]Lee JH, Wood TK, Lee J. Roles of indole as an interspecies and interkingdom signaling molecule. Trends Microbiol. 2015;23(11):707‐718

[2]Huć T, Nowinski A, Drapala A, Konopelski P, Ufnal M. Indole and indoxyl sulfate, gut bacteria metabolites of tryptophan, change arterial blood pressure via peripheral and central mechanisms in rats. Pharmacol Res. 2018;130:172‐179

[3]Patil R, Patil SA, Beaman KD, Patil SA. Indole molecules as inhibitors of tubulin polymerization: potential new anticancer agents, an update (2013-2015). Future Med Chem. 2016;8(11):1291‐1316