iCRT 14

产品说明书

Print
Chemical Structure| 677331-12-3 同义名 : -
CAS号 : 677331-12-3
货号 : A491892
分子式 : C21H17N3O2S
纯度 : 99%
分子量 : 375.444
MDL号 : MFCD04366833
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(79.91 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 iCRT14 has the capability to disrupt TCF binding to DNA, expanding its function beyond influencing TCF-β-cat interaction[1]. In BT-549 cells, iCRT14 administration (10, 25, 50 μM) significantly reduces cell proliferation in a concentration- and time-specific manner, albeit with less potency compared to iCRT3[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.32mL

2.66mL

1.33mL

26.64mL

5.33mL

2.66mL
参考文献

[1]Gonsalves FC, et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci USA. 2011 Apr 12;108(15):5954-63.

[2]Bilir B, et al. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med. 2013 Nov 4;11:280.