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SRPIN340

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Chemical Structure| 218156-96-8 同义名 : SRPK inhibitor
CAS号 : 218156-96-8
货号 : A490626
分子式 : C18H18F3N3O
纯度 : 99%+
分子量 : 349.35
MDL号 : MFCD00116244
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(114.5 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

1% DMSO+30% polyethylene glycol+1% Tween 80+water 8 mg/mL

生物活性
描述 SRPIN340, a serine-arginine-rich protein kinase (SRPK) inhibitor, has a Ki of 0.89 μM for SRPK1 and inhibits SRPK2. It does not significantly affect other SRPKs like Clk1 and Clk4. SRPIN340 leads to the degradation of SRp75, essential for HIV expression, and inhibits the propagation of Sindbis virus and severe acute respiratory syndrome virus with an IC50 of 60 μM [1]. SRPIN340 displays inhibitory effects on leukemia cell lines such as AML HL60, ALL-T Molt4, and Jurkat, with IC50 values of 44.7 μM, 92.2 μM, and 82.3 μM, respectively [2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.86mL

0.57mL

0.29mL

14.31mL

2.86mL

1.43mL

28.62mL

5.72mL

2.86mL
参考文献

[1]Fukuhara T, et al. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11329-33.

[2]Siqueira RP, et al. Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340). PLoS One. 2015 Aug 5;10(8):e0134882.