VTP-27999 HCl

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Chemical Structure| 1264191-73-2 同义名 : VTP-27999 Hydrochloride
CAS号 : 1264191-73-2
货号 : A490325
分子式 : C26H42Cl2N4O5
纯度 : 98+%
分子量 : 561.542
MDL号 : -
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL(178.08 mM)
动物实验配方：
生物活性
描述 VTP-27999 hydrochloride is an alkyl amine Renin inhibitor and is useful for Hypertension and End-Organ Diseases.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.78mL

0.36mL

0.18mL

8.90mL

1.78mL

0.89mL

17.81mL

3.56mL

1.78mL
参考文献

[1]Krop M, Lu X, et al. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-82.

[2]Ishchenko A, Liu Z, et al. Structure-based design technology contour and its application to the design of renin inhibitors. J Chem Inf Model. 2012 Aug 27;52(8):2089-97.