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Angiotensin II human acetate

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Chemical Structure| 68521-88-0 同义名 : 血管紧张素II ;DRVYIHPF acetate;Ang II acetate;Angiotensin II acetate
CAS号 : 68521-88-0
货号 : A489583
分子式 : C52H75N13O14
纯度 : 99.5%
分子量 : 1106.231
MDL号 : MFCD00133092
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 25 mg/mL(22.6 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Angiotensin II human (Angiotensin II), a major bioactive peptide of the renin/angiotensin system, plays a central role in regulating human blood pressure, mainly through interactions with the G-protein-coupled receptors Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). It stimulates sympathetic nervous activity, increases aldosterone biosynthesis and renal actions, and induces growth in vascular smooth muscle cells. It also increases collagen synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and promotes fibrosis and apoptosis. Angiotensin II human acetate stimulates capillary formation from endothelial cells through a LOX-1 dependent redox-sensitive pathway [1][2][3][4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.90mL

0.18mL

0.09mL

4.52mL

0.90mL

0.45mL

9.04mL

1.81mL

0.90mL
参考文献

[1]de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72.

[2]Fyhrquist F, et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24.

[3]Hu C, et al. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway. Hypertension. 2007;50(5):952-957.

[4]Nabah YN, et al. Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines. Circulation. 2004;110(23):3581-3586.

[5]Crowley SD, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90.