产品说明书

Boldine

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Chemical Structure| 476-70-0 同义名 : 波尔定碱 ;2,9-Dihydroxy-1,10-dimethoxyaporphine;NSC 65689;(+)-(S)-Boldine
CAS号 : 476-70-0
货号 : A486761
分子式 : C19H21NO4
纯度 : 98%
分子量 : 327.37
MDL号 : MFCD00135040
存储条件：

粉末 2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(320.74 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Boldine is an aporphine alkaloid, extracted from the leaves and bark of P. boldus, that possesses antioxidant and free-radical scavenging ability. Boldine may contain anti-inflammatory and antiproliferative properties, and the ability to cause cell cycle arrest at the G2/M phase.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.31mL

15.27mL

3.05mL

1.53mL

30.55mL

6.11mL

3.05mL
参考文献

[1]Cermanova J, Prasnicka A, et al. Pharmacokinetics of boldine in control and Mrp2-deficient rats. Physiol Res. 2016 Dec 21;65(Supplementum 4):S489-S497.

[2]Lau YS, Tian XY, et al. Boldine improves endothelial function in diabetic db/db mice through inhibition of angiotensin II-mediated BMP4-oxidative stress cascade. Br J Pharmacol. 2013 Nov;170(6):1190-8.