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3,5-Dinitro-o-toluamide

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Chemical Structure| 148-01-6 同义名 : 二硝托胺 ;Dinitolmide;Zoalene;HSDB7192;Dinitrotoluamide
CAS号 : 148-01-6
货号 : A486438
分子式 : C8H7N3O5
纯度 : 98%
分子量 : 225.158
MDL号 : MFCD00072065
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(466.34 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 2-Methyl-3,5-Dinitrobenzamide can control Eimeria tenella, Eimeria tenella and E. coli, and to inhibit coccidia. Nitromide (3,5-dinitrobenzamide) is reduced to monoamino- and diamino-metabolites in vitro on anaerobic incubation with rat intestinal microflora. This conversion is suppressed by the antibiotics neomycin, tetracycline and bacitracin[3]. Colostomized chickens given oral doses of 3,5-dinitrobenzamide (nitromide) cleared nitromide predominantly through the urine (58% of dose) and feces (21% of dose). Rats cleared 52% of nitromide via urinary excretion and 44% via feces[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.44mL

0.89mL

0.44mL

22.21mL

4.44mL

2.22mL

44.41mL

8.88mL

4.44mL
参考文献

[1]Parks OW, Doerr RC. Liquid chromatographic determination of zoalene and its metabolites in chicken tissues with electrochemical detection. J Assoc Off Anal Chem. 1986 Jan-Feb;69(1):70-1.

[2]Parks OW, et al. J Assoc Off Anal Chem, 1986, 69(1), 70-71.

[3]Facchini V, Griffiths LA. Metabolism of nitromide in the rat. II. Sites of nitro-reduction. Xenobiotica. 1980;10(4):299-305

[4]Shappell NW, Larsen GL, Bakke JE. Identification of the major urinary and fecal metabolites of 3,5-dinitrobenzamide in chickens and rats. Chemosphere. 1999;38(8):1757-1762