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FIIN-2

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Chemical Structure| 1633044-56-0 同义名 : -
CAS号 : 1633044-56-0
货号 : A483586
分子式 : C35H38N8O4
纯度 : 98%
分子量 : 634.727
MDL号 : MFCD28386553
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(47.26 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • FGFR2

    FGFR2, IC50:4.3 nM

  • FGFR3

    FGFR3, IC50:27 nM

  • FGFR4

    FGFR4, IC50:45.3 nM

  • FGFR1

    FGFR1, IC50:3.09 nM
描述 FIIN-2 is an irreversible inhibitor of FGFR1-4 with IC50 values of 3.1, 4.3, 27, and 45 nM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.58mL

0.32mL

0.16mL

7.88mL

1.58mL

0.79mL

15.75mL

3.15mL

1.58mL
参考文献

[1]Huang Z, Tan L, et al. DFG-out mode of inhibition by an irreversible type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors. ACS Chem Biol. 2015 Jan 16;10(1):299-309.

[2]Tan L, Wang J, et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.