Propargyl-PEG5-acid

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Chemical Structure| 1245823-51-1 同义名 : -
CAS号 : 1245823-51-1
货号 : A481703
分子式 : C14H24O7
纯度 : 95%
分子量 : 304.336
MDL号 : MFCD22201536
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(345.01 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Propargyl-PEG5-acid serves as a non-cleavable linker consisting of a 5-unit polyethylene glycol (PEG) chain, utilized in the construction of antibody-drug conjugates (ADCs). It is employed in the formulation of ADC inhibitors targeting Galectin-3. Additionally, Propargyl-PEG5-acid functions as a PEG-based linker for PROTACs, aiding in their synthesis[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.29mL

0.66mL

0.33mL

16.43mL

3.29mL

1.64mL

32.86mL

6.57mL

3.29mL
参考文献

[1]Zhang H, et al. Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors. Bioconjug Chem. 2018 Apr 18;29(4):1266-1275.