WHI-P258

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Chemical Structure| 21561-09-1 同义名 : -
CAS号 : 21561-09-1
货号 : A480267
分子式 : C16H15N3O2
纯度 : 97%
分子量 : 281.309
MDL号 : MFCD01815294
存储条件:

Pure form Keep in dark place,Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 30 mg/mL(106.64 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 WHI-P258 is a quinazoline compound that binds to the active site of JAK3 with an estimated Ki value of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect thrombin-induced platelet aggregation even at a concentration of 100 µM[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.55mL

0.71mL

0.36mL

17.77mL

3.55mL

1.78mL

35.55mL

7.11mL

3.55mL

参考文献

[1]Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82.

[2]Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22.