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Toltrazuril

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Chemical Structure| 69004-03-1 同义名 : 妥曲珠利 ;BAY-i 9142;BAY-Vi-9142;Baycox
CAS号 : 69004-03-1
货号 : A477060
分子式 : C18H14F3N3O4S
纯度 : 98%
分子量 : 425.382
MDL号 : MFCD00867201
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 125 mg/mL(293.85 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Toltrazuril is frequently administered for the metaphylactic control of piglet cystoisosporosis. Toltrazuril has a high efficacy for in the control of parasitological and clinical outcomes of experimental C. suis infection[3]. Already one application of toltrazuril was significantly able to delay the outbreak of neosporosis in newborn mice, when compared to placebo-treated infected controls. However, the number of diseased and Neospora-positive pups (46% and 47%, respectively) was markedly reduced after three-time-toltrazuril treatment compared to all other groups[4]. In piglets, treatment with the recommended (20 mg/kg) dose of toltrazuril completely suppressed oocyst shedding and diarrhea in group Wien-20[5]. Cystoisospora suis causes diarrhoeal disease and reduced weight gain in suckling piglets, and a toltrazuril-based oral suspension is available for treatment. Treatment with both the injectable (Forceris®) and the oral (Baycox®) formulation of toltrazuril in the prepatent period were safe and highly effective against experimental infection with C. suis in newborn piglets[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03383523 Filariasis Phase 1 Completed - United Kingdom ... 展开 >> Hammersmith Medicines Research (HMR) Limited London, United Kingdom, NW10 7EW 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.35mL

0.47mL

0.24mL

11.75mL

2.35mL

1.18mL

23.51mL

4.70mL

2.35mL
参考文献

[1]Enemark HL, Dahl J, Enemark JM. Significance of Timing on Effect of Metaphylactic Toltrazuril Treatment against Eimeriosis in Calves. Parasitol Res. 2015 Aug;114 Suppl 1:S201-12

[2]Iqbal A, Tariq KA, et al. Antiparasitic efficacy of Artemisia absinthium, toltrazuril and amprolium against intestinal coccidiosis in goats. J Parasit Dis. 2013 Apr;37(1):88-93.

[3]Joachim A, Guerra N, Hinney B, et al. Efficacy of injectable toltrazuril-iron combination product and oral toltrazuril against early experimental infection of suckling piglets with Cystoisospora suis. Parasit Vectors. 2019;12(1):272. Published 2019 May 28

[4]Strohbusch M, Müller N, Hemphill A, Krebber R, Greif G, Gottstein B. Toltrazuril treatment of congenitally acquired Neospora caninum infection in newborn mice. Parasitol Res. 2009;104(6):1335‐1343

[5]Shrestha A, Freudenschuss B, Jansen R, Hinney B, Ruttkowski B, Joachim A. Experimentally confirmed toltrazuril resistance in a field isolate of Cystoisospora suis. Parasit Vectors. 2017;10(1):317. Published 2017 Jun 29

[6]Joachim A, Shrestha A, Freudenschuss B, et al. Comparison of an injectable toltrazuril-gleptoferron (Forceris®) and an oral toltrazuril (Baycox®) + injectable iron dextran for the control of experimentally induced piglet cystoisosporosis. Parasit Vectors. 2018;11(1):206. Published 2018 Mar 27