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Isoquercitrin

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Chemical Structure| 21637-25-2 同义名 : 槲皮素-3-氧葡萄糖甙 ;Isoquercitroside;Quercetin 3-(β-D-glucofuranoside);Quercetin 3-O-β-D-glucofuranoside
CAS号 : 21637-25-2
货号 : A475548
分子式 : C21H20O12
纯度 : 95%
分子量 : 464.376
MDL号 : MFCD29050128
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(258.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Isoquercitrin (Isoquercitroside) is an effective antioxidant and an eosinophilic inflammation suppressor. 10 μM of Isoquercitrin of the seven compounds (myricitrin, isoquercitrin, hypoletin-7-O-β-D-xylopyranoside, quercitrin, kaempferin, kaempferol, and amentoflavone) partially but significantly blunt the negative effect of H2O2 on RGC-5 cells, as the viability of cells in the presence of H2O2 is increased from approximately 63% to 83% and 90% at 10 and 50 μM, respectively. Indeed, 50 μM Isoquercitrin is more effective as a neuroprotectant than the same concentration of EGCG. Furthermore, isoquercitrin potently attenuated the lipid peroxidation of rat brain homogenates initiated by nitric oxide, with an IC(50) value of 1.04 μM[3]. Isoquercitrin was effective in alleviating soleus muscle mass loss following denervation in a dose-dependent manner (the optimal protective effect at 20 mg/kg/d). Isoquercitrin may alleviate soleus muscle atrophy and mitophagy and reverse the slow-to-fast fiber type conversion following denervation via inhibition of oxidative stress and inflammatory response[4]. Treatment with ISO (Isoquercitrin) largely rescues STZ(streptozotocin)-induced differentiation inhibition and enhances neurite outgrowth of Neuro2a (N2a) cells in vitro. Moreover, oral administration of ISO protects hippocampal neurons from STZ-induced neurotoxicity and significantly improves the cognitive and behavioural impairment in STZ-induced AD rats[5]. Isoquercitrin is also effective eosinophilic inflammation suppressors, suggesting a potential for treating allergies[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.22mL

10.77mL

2.15mL

1.08mL

21.53mL

4.31mL

2.15mL
参考文献

[1]Jung SH, et al. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem Int. 2010 Dec;57(7):713-21.

[2]Rogerio AP, et al. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8.

[3]Jung SH, Kim BJ, Lee EH, Osborne NN. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells). Neurochem Int. 2010 Dec;57(7):713-21

[4]Shen Y, Zhang Q, Huang Z, Zhu J, Qiu J, Ma W, Yang X, Ding F, Sun H. Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation. Front Physiol. 2020 Aug 12;11:988

[5]Chen L, Feng P, Peng A, Qiu X, Lai W, Zhang L, Li W. Protective effects of isoquercitrin on streptozotocin-induced neurotoxicity. J Cell Mol Med. 2020 Sep;24(18):10458-10467

[6]Rogerio AP, Kanashiro A, Fontanari C, da Silva EV, Lucisano-Valim YM, Soares EG, Faccioli LH. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. Inflamm Res. 2007 Oct;56(10):402-8