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L-778123 HCl

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Chemical Structure| 253863-00-2 同义名 : L-778,123 (hydrochloride);L-778123 hydrochloride
CAS号 : 253863-00-2
货号 : A474613
分子式 : C22H21Cl2N5O
纯度 : 98%
分子量 : 442.341
MDL号 : MFCD09970379
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(56.52 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 25 mg/mL(56.52 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.26mL

0.45mL

0.23mL

11.30mL

2.26mL

1.13mL

22.61mL

4.52mL

2.26mL
参考文献

[1]Ghasemi S, Davaran S, et al. Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-7.

[2]Lobell RB, Liu D, Buser CA, et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-58.