PIK-90

产品说明书

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Chemical Structure| 677338-12-4 同义名 : PIK-85
CAS号 : 677338-12-4
货号 : A474202
分子式 : C18H17N5O3
纯度 : 99%+
分子量 : 351.359
MDL号 : MFCD12910483
存储条件：

Pure form Keep in dark place,Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 5 mg/mL(14.23 mM)，配合低频超声，并调节pH至2，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • p110γ

    PI3Kγ, IC50:18 nM

  • p110β

    PI3Kβ, IC50:350 nM

  • p110α

    PI3Kα, IC50:11 nM

  • p110δ

    PI3Kδ, IC50:58 nM
描述 PIK-90 is a PI3Kα/γ/δ inhibitor with IC50 of 11 nM/18 nM/58 nM, respectively, less potent to PI3Kβ (IC50= 350 nM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.85mL

0.57mL

0.28mL

14.23mL

2.85mL

1.42mL

28.46mL

5.69mL

2.85mL
参考文献

[1]Niedermeier M, Hennessy BT, et al. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach Blood. 2009 May 28;113(22):5549-57.

[2]Van Keymeulen A, Wong K, et al. To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol. 2006 Jul 31;174(3):437-45. Epub 2006 Jul 24.