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KN-93 HCl

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Chemical Structure| 1956426-56-4 同义名 : KN-93 (hydrochloride);KN-93 hydrochloride
CAS号 : 1956426-56-4
货号 : A469420
分子式 : C26H30Cl2N2O4S
纯度 : 99%+
分子量 : 537.498
MDL号 : MFCD27992054
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(55.81 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Treatment with KN-93 for two days results in the arrest of 95% of cells in the G1 phase of the cell cycle, with this arrest being reversible. Following the cessation of KN-93 treatment, a significant number of cells advance to the S and G2-M phases. KN-93 effectively inhibits cell growth induced by various growth factors such as basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts[1]. KN-93 has been found to inhibit H+, K+-ATPase activity, disrupt the proton gradient across gastric membrane vesicles, and decrease the volume of the luminal space[2]. Furthermore, KN-93 at a concentration of 0.5 μM prevents an increase in left ventricular developed pressure during action potential prolongation and early afterdepolarizations. It also inhibits the rise in Ca2+-independent CaM kinase activity observed during early afterdepolarizations[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.30mL

1.86mL

0.93mL

18.60mL

3.72mL

1.86mL
参考文献

[1]Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep;6(9):1063-70.

[2]Li J, et al. Curcumin Attenuates Retinal Vascular Leakage by Inhibiting Calcium/Calmodulin-Dependent Protein Kinase II Activity in Streptozotocin-Induced Diabetes. Cell Physiol Biochem. 2016;39(3):1196-208.

[3]Mamiya N, et al. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitorKN-93. Biochem Biophys Res Commun. 1993 Sep 15;195(2):608-15.