产品说明书

Limaprost

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Chemical Structure| 74397-12-9 同义名 : 17α,20-dimethyl-δ2-PGE1;OP1206;17α,20-dimethyl-Δ2-Prostaglandin E1;ONO1206
CAS号 : 74397-12-9
货号 : A465257
分子式 : C22H36O5
纯度 : 98%
分子量 : 380.518
MDL号 : MFCD00868275
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(105.12 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Limaprost is a PGE1 analog and potent platelet adhesion inhibitor.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01888536 Neurologic Claudication in Pat... 展开 >>ients With Lumbar Spinal Stenosis 收起 << Phase 4 Completed - Korea, Republic of ... 展开 >> Hallym University Sacred Heart Hospital Anyang-si, Gyeonggi-do, Korea, Republic of, 431-070 Hanyang University Guri Hospital Guri-si, Gyeonggi-do, Korea, Republic of, 471-701 Seoul National University Bundang Hospital Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707 Yonsei University Health System, Severance Hospital Seoul, Korea, Republic of, 120-752 KyungHee University Medical Center Seoul, Korea, Republic of, 130-872 Inje University Sanggye Paik Hospital Seoul, Korea, Republic of, 139-707 SMG-SNU Boramae Medical Center Seoul, Korea, Republic of, 156-707 收起 <<
NCT02125981 Cervical Myelopathy Phase 3 Recruiting December 2018 Korea, Republic of ... 展开 >> Seoul National University Bundang Hospital Recruiting Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707 Contact: Jin S. Yeom, MD    +82-31-787-7915    highcervical@gmail.com    Principal Investigator: Jin S. Yeom, MD 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.63mL

0.53mL

0.26mL

13.14mL

2.63mL

1.31mL

26.28mL

5.26mL

2.63mL
参考文献

[1]Moribe K, Sekiya N, et al. Stabilization mechanism of limaprost in solid dosage form. Int J Pharm. 2007 Jun 29;338(1-2):1-6.

[2]Tsuboi T, Hatano N, et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn Ther. 1980 Sep;247(1):89-102.