产品说明书

Cligosiban

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Chemical Structure| 900510-03-4 同义名 : PF-3274167
CAS号 : 900510-03-4
货号 : A464505
分子式 : C19H19ClFN5O3
纯度 : 99%+
分子量 : 419.837
MDL号 : MFCD25976681
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(119.09 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cligosiban (PF-3274167), a non-peptide oxytocin receptor antagonist with high oral bioavailability and good brain penetration, exhibits high affinity (Ki=9.5 nM) and excellent selectivity against vasopressin receptors, particularly V1b and V1a subtypes. Cligosiban inhibits ejaculatory physiology in rodents[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.91mL

2.38mL

1.19mL

23.82mL

4.76mL

2.38mL
参考文献

[1]Chunwan Lu, et al. Small molecule histone methyltransferase SUV39H1 inhibitor and uses thereof. US10577371B2. 2018.