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NVP-AEW541

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Chemical Structure| 475489-16-8 同义名 : AEW541
CAS号 : 475489-16-8
货号 : A462988
分子式 : C27H29N5O
纯度 : 99%+
分子量 : 439.552
MDL号 : MFCD22741515
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(113.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • IGF-1R

    IGF-1R, IC50:0.15 μM

  • Insulin Receptor

    Insulin Receptor, IC50:0.14 μM
描述 NVP-AEW541 (AEW541) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 of 0.15 μM. It also inhibits the insulin receptor (InsR) with an IC50 of 0.14 μM, showcasing significant antitumor activity[1].
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
32D-Bcr-Abl ~10 μM Kinase assay inhibits Bcr-Abl p210 with IC50 of >10 μM 15050915
6647 ~7 μM Growth inhibitory assay IC50<0.5 μM 15867386
A14 ~10 μM Kinase assay inhibits InsR with IC50 of 2.3 ± 0.163 μM 15050915
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.38mL

2.28mL

1.14mL

22.75mL

4.55mL

2.28mL
参考文献

[1]García-Echeverría C, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004 Mar;5(3):231-9.

[2]Tanno B, et al. Down-regulation of IGF-1 receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Clin Cancer Res. 2006, 12(22), 6772-6780.