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PDTC ammonium

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Chemical Structure| 5108-96-3 同义名 : 吡咯烷二硫代甲酸铵盐;吡咯烷二硫代甲酸铵;1-吡咯烷二硫代甲酸铵 ;Pyrrolidinedithiocarbamate ammonium；Ammonium pyrrolidinedithiocarbamate;MUN 08963;Ammonium 1-Pyrrolidinecarbodithioate. PDTC. APDC.;Pyrrolidinedithiocarbamate;Pyrrolidinedithiocarbamic Acid (ammonium salt);Pyrrolidine dithiocarbamic acid ammonium salt;PDTC;APDC
CAS号 : 5108-96-3
货号 : A462174
分子式 : C5H12N2S2
纯度 : 98%
分子量 : 164.292
MDL号 : MFCD00012720
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO：70 mg/ml 426.07mM，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • NF-κB
描述 Pyrrolidinedithiocarbamate ammonium, ranging from 3 to 1000 μM, when used as a pretreatment, dose-dependently reduces IL-8 production in cells[1]. Pyrrolidinedithiocarbamate ammonium functions by inhibiting the activation of NF-κB, effectively diminishing both NF-κB DNA binding and its dependent transcriptional activity. Consequently, the inhibition of NF-κB with pyrrolidinedithiocarbamate ammonium results in decreased IL-8 production by intestinal epithelial cells, underscoring its mechanism of action[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.09mL

1.22mL

0.61mL

30.43mL

6.09mL

3.04mL

60.87mL

12.17mL

6.09mL
参考文献

[1]Németh ZH, et al. Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells. Immunol Lett. 2003 Jan 2;85(1):41-6.

[2]Qin JD, et al. Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and CYP2E1 content of rats with immunological liver injury. Pharm Biol. 2014 Nov;52(11):1460-1466.