产品说明书
Isodiospyrin
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同义名 : | - |
| CAS号 : | 20175-84-2 | |
| 货号 : | A461958 | |
| 分子式 : | C22H14O6 | |
| 纯度 : | 98+% | |
| 分子量 : | 374.34 | |
| MDL号 : | MFCD20260856 | |
| 存储条件： |
粉末 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Isodiospyrin, a natural product isolated and purified from the herbs of Diospyros morrisiana, exhibits remarkably good antifungal activity, the MIC values of the isodiospyrin was 5-160 μg/mL & the MFC values was 40-160 μg/mL. Isodiospyrin has a broad spectrum of antibacterial activity. The MIC values of isodiospyrin against Gram-positive bacteria ranged from 0.78 to 50 mg/mL. While those against Pseudomonas aeruginosa ATCC 15443 and S. typhi ranged from 50 to 100 mg/mL.exhibits cytotoxic activity to tumor cell lines. It also inhibits hTOPO I by direct binding to htopo I, which limits hTOPO I access to the DNA substrate, and exhibits strong inhibitory effect on the kinase activity of htopo I toward splicing factor 2/alternate splicing factor in the absence of DNA. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.67mL 0.53mL 0.27mL |
13.36mL 2.67mL 1.34mL |
26.71mL 5.34mL 2.67mL |
| 参考文献 |
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