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Schisandrin

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Chemical Structure| 7432-28-2 同义名 : Schizandrin;Schizandrol;Wuweizins;Schisandrol A;Omija;Magnolia Vine;Gomisins;(+)-Schizandrin;Schizandrol-A
CAS号 : 7432-28-2
货号 : A458424
分子式 : C24H32O7
纯度 : 98%
分子量 : 432.507
MDL号 : -
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(2.31 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Schizandrin is a major bioactive constituent of Schisandra chinensis (Turcz.) Baill with antioxidant and anti-inflammatory properties. Schizandrin prevented LPS-induced injury in the H9c2 cells and promoted the recovery of myocardial tissues by enhancing cell viability and migration[3]. Sch A specifically reverses P-gp-mediated DOX resistance in MCF-7/DOX cells by blocking P-gp, NF-κB, and Stat3 signaling. Inhibition of P65 and Stat3 shows potent anti-MDR (Multidrug resistance) effect on MCF-7/DOX cells[4]. Schizandrin (1 and 10 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of spatial memory. Similarly, schizandrin (1 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of the passive avoidance response. Moreover, in mice, schizandrin (1 and 10 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M(1) receptor agonist[5]. Pretreatment of the cortical cell cultures with schizandrin (10, 100 microM) for 2 h significantly protected cortical neurons against Glu-induced excitotoxicity. The neuroprotective activity of schizandrin was the most potent at the concentration of 100 microM. In addition, schizandrin diminished the intracellular Ca2+ influx, inhibited the subsequent overproduction of nitric oxide (NO), reactive oxygen species (ROS), and cytochrome c, and preserved the mitochondrial membrane potential. Furthermore, schizandrin also increased the cellular level of glutathione (GSH) and inhibited the membrane lipid peroxidation malondialdehyde (MDA)[6]. Schizandrin can be used to treat inflammatory and atopic diseases through the inhibition of TSLP(Thymic stromal lymphopoietin) [7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.31mL

0.46mL

0.23mL

11.56mL

2.31mL

1.16mL

23.12mL

4.62mL

2.31mL
参考文献

[1]Lu Y, Wang WJ, et al. The protective mechanism of schisandrin A in d-galactosamine-induced acute liver injury through activation of autophagy. Pharm Biol. 2014 Oct;52(10):1302-7.

[2]Wang CP, Li GC, et al. Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons. J Physiol Biochem. 2014 Sep;70(3):735-47.

[3]Zhang X, Zhao Y, Bai D, Yuan X, Cong S. Schizandrin protects H9c2 cells against lipopolysaccharide-induced injury by downregulating Smad3. J Biochem Mol Toxicol. 2019 May;33(5):e22301

[4]Zhang ZL, Jiang QC, Wang SR. Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation. Breast Cancer. 2018 Mar;25(2):233-242

[5]Egashira N, Kurauchi K, Iwasaki K, Mishima K, Orito K, Oishi R, Fujiwara M. Schizandrin reverses memory impairment in rats. Phytother Res. 2008 Jan;22(1):49-52

[6]Cheng HY, Hsieh MT, Wu CR, Tsai FH, Lu TC, Hsieh CC, Li WC, Lin YT, Peng WH. Schizandrin protects primary cultures of rat cortical cells from glutamate-induced excitotoxicity. J Pharmacol Sci. 2008 May;107(1):21-31.

[7]Moon PD, Jeong HJ, Kim HM. Effects of schizandrin on the expression of thymic stromal lymphopoietin in human mast cell line HMC-1. Life Sci. 2012 Oct 5;91(11-12):384-388