产品说明书

Isoxicam

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Chemical Structure| 34552-84-6 同义名 : -
CAS号 : 34552-84-6
货号 : A457768
分子式 : C14H13N3O5S
纯度 : 97%
分子量 : 335.335
MDL号 : MFCD00079374
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(11.93 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Isoxicam is an orally administered, long-acting, non-steroidal anti-inflammatory drug used in arthritis research. It functions as a nonselective inhibitor of both COX-1 and COX-2 enzymes[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.98mL

0.60mL

0.30mL

14.91mL

2.98mL

1.49mL

29.82mL

5.96mL

2.98mL
参考文献

[1]DiPasquale G, et al. The antiinflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide). Agents Actions. 1975 Aug;5(3):256-63.

[2]Xu S, et al. Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network. J Biol Chem. 2014 Mar 7;289(10):6799-808.